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pentobarbital will minimize the level or impact of ixabepilone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.pentobarbital will reduce the level or influence of etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital will lessen the level or outcome of ketoconazole by i